Zane first made his mark on the Hollywood scene with his chilling breakout performance opposite Nicole Kidman and Sam Neill in the 1989 thriller Dead Calm. His other feature film credits include starring roles in the political actioner Sniper, the westerns Tombstone and Posse, the WWII drama Memphis Belle, the romantic comedy Only You, and the adaptation of the Virginia Woolf novel Orlando.

Zane also starred with Jada Pinkett in Tales from the Crypt Presents Demon Knight, produced by Joel Silver and Robert Zemeckis, and played the virtuous hero in the adventure film The Phantom, co-starring Catherine Zeta Jones. His portrayal of Cal Hockley in the worldwide blockbuster Titanic garnered Zane numerous honors, including a Blockbuster Entertainment Award for Favorite Actor, a Screen Actor's Guild Award nomination, and an MTV Movie Award nomination. Zane also plays himself in the comedy Zoolander, directed by and starring Ben Stiller.

Zane began compiling a list of producing credits with This World, Then The Fireworks, in which he also starred with Gina Gershon. The film premiered to critical acclaim in the prestigious American Spectrum series at the Sundance Film Festival, and also played at the Cannes Film Festival in 1997. He also produced 1998's I Woke Up Early the Day I Died.

On television, Zane has starred as Marc Antony in the epic miniseries Cleopatra, which aired to critical acclaim on ABC, and received critical honors for his starring role in Dean Koontz's thriller Sole Survivor, which aired on Fox. He also stars in The Believer for Showtime (which won the Grand Jury Prize at the Sundance Film Festival), and in the TBS original movie Invincible, produced by Mel Gibson and Jet Li. In addition, Zane has a recurring guest-starring role on David E. Kelly's critically acclaimed series Boston Public.

  Kurtlar vadisi - Irak (2006) .... Sam
Kingdom Hearts II (2005) (VG) (voice) .... Ansem/DiZ
Mem-o-re (2005) .... Taylor Briggs
BloodRayne (2005) .... Elrich
The Last Drop (2005) .... Oates
The Pleasure Drivers (2005) .... Marvin
Lest We Forget: The Video Collection (2004) (V) .... Agent In Limo
Bet Your Life (2004) (TV) .... Joseph
Silver City (2004) .... Chandler Tyson
Big Kiss (2004) .... Billy
Dead Fish (2004) .... Virgil
Three (2004) .... Jack
The Kiss (2003) (V) .... Alan Roberts/young Philip Naudet
Vlad (2003) .... Adrian
Silent Warnings (2003) (V) .... Sheriff Bill Willingham
Imaginary Grace (2003) .... Nero
Starving Hysterical Naked (2003)
Claim (2002) .... Roberto Bealing
Landspeed (2002) .... Michael Sanger
Kingdom Hearts (2002) (VG) (voice) .... Ansem
Invincible (2001/I) (TV) .... Os
The Diamond of Jeru (2001) (TV) .... Mike Kardec
SSX Tricky (2001) (VG) (voice) .... Broderick 'Brodi' Ford
CQ (2001) .... Mr. E
The Believer (2001) .... Curtis Zampf
Hendrix (2000) (TV) .... Michael Jeffrey
"Sole Survivor" (2000) (mini) TV Series .... Joe Carpenter
Taxman (1999/II) .... George Putter
Cleopatra (1999) (TV) .... Marc Antony
God Is in the T.V. (1999) (V) .... Yuppie in limo (segment "The Dope Show")
Morgan's Ferry (1999) .... Sam
Susan's Plan (1998) .... Sam Myers
I Woke Up Early the Day I Died (1998) .... The Thief
Pocahontas II: Journey to a New World (1998) (V) (voice) .... John Rolfe
Titanic (1997) .... Caledon 'Cal' Hockley
This World, Then the Fireworks (1997) .... Marty Lakewood
Danger Zone (1997) .... Rick Morgan
Head Above Water (1996) .... Kent
The Phantom (1996) .... The Phantom/Kit Walker
Demon Knight (1995) .... The Collector
The Set Up (1995) .... Charles Thorpe
Only You (1994) .... Harry, The False Damon Bradley
Running Delilah (1994) (TV) .... Paul
Silenzio dei prosciutti, Il (1994) .... Jo Dee Foster
Reflections on a Crime (1994) .... Colin
Tombstone (1993) .... Mr. Fabian
Poetic Justice (1993) .... Brad
Posse (1993) .... Colonel Graham
Lake Consequence (1993) (TV) .... Billy
Sniper (1993) .... Richard Miller
Betrayal of the Dove (1993) .... Dr. Jesse Peter
Flashfire (1993) .... Jack Flinder
Orlando (1992) .... Shelmerdine
Blood and Concrete (1991) .... Joey Turks
Femme Fatale (1991) .... Elijah
Miliardi (1991) .... Maurizio Ferretti
Memphis Belle (1990) .... Lt. Val Kozlowski
Megaville (1990) .... Palinov/Jensen
Back to the Future Part II (1989) .... Match
Dead Calm (1989) .... Hughie Warriner
The Case of the Hillside Stranglers (1989) (TV) .... Kenneth Bianchi
Going Overboard (1989) .... King Neptune
Police Story: Monster Manor (1988) (TV) .... Officer Don Varney
Conspiracy: The Trial of the Chicago 8 (1987) (TV) .... Police Officer
Critters (1986) .... Steve Elliot
Brotherhood of Justice (1986) (TV) .... Les
Back to the Future (1985) .... Match